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Fioricet

$329.00$659.00

The combination of butalbital and acetaminophen along with caffeine makes up the magical
composition which is used to make fioricet. This drug is used to treat headaches which are
either tension related or migraine related. The butalbital part is a form of barbiturate while
the acetaminophen acts as an analgesic, the caffeine parts add upon to be from the
xanthine category.

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EVERYTHING YOU NEED TO KNOW ABOUT FIORICET

INTRODUCTION TO FIORICET

In this article we are going to learn about the drug fioricet, which is a combination medicine used to treat headaches generated by tensions. We are going to discuss composition and clinical relevancy of fioricet along with the therapeutic and medicinal uses, adverse reactions and safety precautions.

The combination of butalbital and acetaminophen along with caffeine makes up the magical composition which is used to make fioricet. This drug is used to treat headaches which are either tension related or migraine related. The butalbital part is a form of barbiturate while the acetaminophen acts as an analgesic, the caffeine parts add upon to be from the xanthine category.

CLINICAL DATA RELEVANT TO THE DRUG FIORICRT.

• Combination medication made of: butalbital /acetaminophen / caffeine.

• Trade name: anoquan, fioricet, triad, amongst others.

• Routes of administration of drug: oral route [ by mouth]

• Metabolism and excretion: butalbital is ideally eliminated by the kidneys as an unchanged form of drug, but acetaminophen and caffeine are metabolised in the liver and are excreted by the kidneys.

• Duration of action: 4 to 6 hours. Reaches the peak within 2hours of intake.

 

MECHANISM OF ACTION OF FIORICET.

The mechanism of action of this combination of drug occurs when the butalbital, affects the central nervous system by exerting a depressing effect, when it is taken in higher number of doses, it can exert peripheral effects too. Acetaminophen [paracetamol] which is an analgesic and an antipyretic drug, has its effects mediated by a metabolite which acts on the cannabinoid receptors which are located throughout the body [ cell membrane receptors]. On the other hand, caffeine brings about vasoconstriction in blood vessels of the cerebellar system, this vasoconstriction serves to counteract the sedative effect produced by
butalbital. Half life of butalbital is about 35hours, while acetaminophen has a half life of 1.5 to 2 hours but there can be significant increase after an overdose or damaged liver, and the half life of caffeine id said to be 2.5 to 4.5 hours by the experts.

WHAT ARE THE MEDICAL USES AND THERAPEUTIC USES OF FIORICET?

The combination medication which is emerging as a life saving drug in the treatment of tension headaches mainly. Due to the acetaminophen properties it is also used for managing fever and overall pain along with uses in migraine headaches, while, the butalbital in the combination helps in relaxation of the muscle contraction that takes place during the headache to a patient, the caffeine which stimulates the central nervous system helps in improving the blood flow to cerebellar arteries and its parts. Fioricet is used when our over the counter drugs have not shown the desired results in managing and suppressing the pain.

ADVERSE REACTION, SIDE EFFECTS CAUSED BY THIS DRUG FIORICET.

The side effects that are commonly reported by the patients who have been administered this drug includes feeling of pleasure, excitement or happiness, dizziness and light headedness, moderate to severe drowsiness along with sedative effects, felling of nausea, vomiting and constipation, along with features that include intoxication like symptoms, shortness of breath and dyspnoea and pain in the abdominal region. Prolonged usage of the drug can cause rebound headaches to the patients. Stevens Johnson syndrome is reported by few patients which is a very rarely occurring phenomenon developed by continuous use
of barbiturates.

IS FIORICET OVERDOSE FATAL? TREATMENT AND PREVENTION OF OVERDOSE.

Fioricet overdose is proven to be fatal in many reported cases as the butalbital shows its toxicity by producing excessive sedative effects which in turn causes respiratory depression in the patients, leading to death via hypoxia [ deprivation of body or part of body to supply of adequate oxygen]. Non-lethal form of overdoses also includes a patient to be in coma or death. Acetaminophen exerts its toxicity via production of toxic metabolite which can cause the liver to damage at doses as low as four grams. Larger doses can cause multiple problems like acute liver failure, acute kidney injury or gastrointestinal bleeding. There are reports of deaths which have occurred due to ingestion of ten to fifteen grams of metabolites due to organ dysfunction.

TREATMENT REGIME FOR OVERDOSE

Treatment for the acetaminophen overdose includes antidote N-acetylcysteine. While there is no specific treatment for overdose caused by barbiturate butalbital, the supportive treatment includes administration of intravenous saline, naloxone, thiamine, glucose, sodium bicarbonate to improve the rate of excretion.

PREVENTION OF OVERDOSE AND DEPENDENCY INCLUDES:

The prescribed dosage of fioricet should be decided by a well qualified heath care provider.The dosage should be decided on the basis of severity of the condition, patient age, liver or kidney dysfunction and while taking in mind several other factors like ongoing medication if any, breathlessness or respiratory condition and etc. the patient and his/her family are to be made aware of all the side effects of the combination of the drug along with creating awareness about potential risks of developing a dependency to the patients. On experiencing any severe symptoms, the patient should report to the hospital for immediate
action.

CONCLUSION:

To summarise the content of the article, fioricet is a combination of three different category of drug like barbiturate, analgesic and xanthine. Arising from these categories are butalbital, acetaminophen [paracetamol], and caffeine, respectively. This combination of drug is used in treatment of headaches that are arising from either tension or migration, due to the antipyretic activity of acetaminophen, it is also given to patients with overall body pain and fever. With every drug and its therapeutic uses comes its adverse effects and side effects, which ranges from commonly occurring side effects like dizziness, euphoria, nausea,
vomiting and etc to rarely seen effects such as Stevens Johnson syndrome. The drug fioricet has an high potential to develop dependency and cause overdose when taken unsupervised and without the guidance of a skilled doctor. Therefore, utmost care should be taken in dealing with such patients.

Quantity

180 Pills, 360 Pills

Delivery Time

3 to 5 Days, 8 to 10 Days

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